Prevention of Influenza Pneumonitis by Sialic Acid–Conjugated Dendritic Polymers
Identifieur interne : 001759 ( Main/Exploration ); précédent : 001758; suivant : 001760Prevention of Influenza Pneumonitis by Sialic Acid–Conjugated Dendritic Polymers
Auteurs : Jeffrey J. Landers ; Zhengyi Cao ; Inhan Lee ; Lars T. Piehler ; Piotr P. Myc ; Andrzej Myc ; Tarek Hamouda ; Andrzej T. Galecki ; James R. BakerSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2002.
Descripteurs français
- KwdFr :
- Acides sialiques (), Acides sialiques (synthèse chimique), Acides sialiques (usage thérapeutique), Animaux, Conception de médicament, Conformation moléculaire, Données de séquences moléculaires, Grippe humaine (), Humains, Hémagglutination, Modèles moléculaires, Pneumopathie infectieuse (), Pneumopathie infectieuse (virologie), Polyamines, Polymères (), Polymères (synthèse chimique), Polymères (usage thérapeutique), Poumon (), Poumon (virologie), Souris, Séquence glucidique, Virus de la grippe A (), Virus de la grippe A (pathogénicité).
- MESH :
- pathogénicité : Virus de la grippe A.
- synthèse chimique : Acides sialiques, Polymères.
- usage thérapeutique : Acides sialiques, Polymères.
- virologie : Pneumopathie infectieuse, Poumon.
- Acides sialiques, Animaux, Conception de médicament, Conformation moléculaire, Données de séquences moléculaires, Grippe humaine, Humains, Hémagglutination, Modèles moléculaires, Pneumopathie infectieuse, Polyamines, Polymères, Poumon, Souris, Séquence glucidique, Virus de la grippe A.
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adhesion, Amidoamine polymer, Animals, Antiviral, Carbohydrate Sequence, Drug Design, Hemagglutination, Human, Humans, Infection, Influenza A virus (classification), Influenza A virus (pathogenicity), Influenza, Human (complications), Influenzavirus, Lung (drug effects), Lung (virology), Mice, Models, Molecular, Molecular Conformation, Molecular Sequence Data, Plasma membrane, Pneumonia (prevention & control), Pneumonia (virology), Pneumopathy, Polyamines, Polymers (chemical synthesis), Polymers (chemistry), Polymers (therapeutic use), Prevention, Sialic Acids (chemical synthesis), Sialic Acids (chemistry), Sialic Acids (therapeutic use), Sialic acid, Specificity, Viral disease.
- MESH :
- chemical , chemical synthesis : Polymers, Sialic Acids.
- chemical , chemistry : Polymers, Sialic Acids.
- chemical , therapeutic use : Polymers, Sialic Acids.
- chemical : Polyamines.
- classification : Influenza A virus.
- complications : Influenza, Human.
- drug effects : Lung.
- pathogenicity : Influenza A virus.
- prevention & control : Pneumonia.
- virology : Lung, Pneumonia.
- Animals, Carbohydrate Sequence, Drug Design, Hemagglutination, Humans, Mice, Models, Molecular, Molecular Conformation, Molecular Sequence Data.
Abstract
Influenza A viral infection begins by hemagglutinin glycoproteins on the viral envelope binding to cell membrane sialic acid (SA). Free SA monomers cannot block hemagglutinin adhesion in vivo because of toxicity. Polyvalent, generation 4 (G4) SA-conjugated polyamidoamine (PAMAM) dendrimer (G4-SA) was evaluated as a means of preventing adhesion of 3 influenza A subtypes (H1N1, H2N2, and H3N2). In hemagglutination-inhibition assays, G4-SA was found to inhibit all H3N2 and 3 of 5 H1N1 influenza subtype strains at concentrations 32–170 times lower than those of SA monomers. In contrast, G4-SA had no ability to inhibit hemagglutination with H2N2 subtypes or 2 of 5 H1N1 subtype strains. In vivo experiments showed that G4-SA completely prevented infection by a H3N2 subtype in a murine influenza pneumonitis model but was not effective in preventing pneumonitis caused by an H2N2 subtype. Polyvalent binding inhibitors have potential as antiviral therapeutics, but issues related to strain specificity must be resolved
Url:
DOI: 10.1086/344316
Affiliations:
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Le document en format XML
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Baker</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="2002-11-01">2002</date><biblScope unit="vol">186</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1222">1222</biblScope><biblScope unit="page" to="1230">1230</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adhesion</term><term>Amidoamine polymer</term><term>Animals</term><term>Antiviral</term><term>Carbohydrate Sequence</term><term>Drug Design</term><term>Hemagglutination</term><term>Human</term><term>Humans</term><term>Infection</term><term>Influenza A virus (classification)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza, Human (complications)</term><term>Influenzavirus</term><term>Lung (drug effects)</term><term>Lung (virology)</term><term>Mice</term><term>Models, Molecular</term><term>Molecular Conformation</term><term>Molecular Sequence Data</term><term>Plasma membrane</term><term>Pneumonia (prevention & control)</term><term>Pneumonia (virology)</term><term>Pneumopathy</term><term>Polyamines</term><term>Polymers (chemical synthesis)</term><term>Polymers (chemistry)</term><term>Polymers (therapeutic use)</term><term>Prevention</term><term>Sialic Acids (chemical synthesis)</term><term>Sialic Acids (chemistry)</term><term>Sialic Acids (therapeutic use)</term><term>Sialic acid</term><term>Specificity</term><term>Viral disease</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides sialiques ()</term><term>Acides sialiques (synthèse chimique)</term><term>Acides sialiques (usage thérapeutique)</term><term>Animaux</term><term>Conception de médicament</term><term>Conformation moléculaire</term><term>Données de séquences moléculaires</term><term>Grippe humaine ()</term><term>Humains</term><term>Hémagglutination</term><term>Modèles moléculaires</term><term>Pneumopathie infectieuse ()</term><term>Pneumopathie infectieuse (virologie)</term><term>Polyamines</term><term>Polymères ()</term><term>Polymères (synthèse chimique)</term><term>Polymères (usage thérapeutique)</term><term>Poumon ()</term><term>Poumon (virologie)</term><term>Souris</term><term>Séquence glucidique</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Polymers</term><term>Sialic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Polymers</term><term>Sialic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Polymers</term><term>Sialic Acids</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Polyamines</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Acides sialiques</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acides sialiques</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Pneumopathie infectieuse</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Pneumonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Carbohydrate Sequence</term><term>Drug Design</term><term>Hemagglutination</term><term>Humans</term><term>Mice</term><term>Models, Molecular</term><term>Molecular Conformation</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acides sialiques</term><term>Animaux</term><term>Conception de médicament</term><term>Conformation moléculaire</term><term>Données de séquences moléculaires</term><term>Grippe humaine</term><term>Humains</term><term>Hémagglutination</term><term>Modèles moléculaires</term><term>Pneumopathie infectieuse</term><term>Polyamines</term><term>Polymères</term><term>Poumon</term><term>Souris</term><term>Séquence glucidique</term><term>Virus de la grippe A</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adhérence</term><term>Amidoamine polymère</term><term>Antiviral</term><term>Homme</term><term>Hémagglutination</term><term>Infection</term><term>Influenzavirus</term><term>Membrane plasmique</term><term>Pneumopathie</term><term>Prévention</term><term>Sialique acide</term><term>Spécificité</term><term>Virose</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Influenza A viral infection begins by hemagglutinin glycoproteins on the viral envelope binding to cell membrane sialic acid (SA). Free SA monomers cannot block hemagglutinin adhesion in vivo because of toxicity. Polyvalent, generation 4 (G4) SA-conjugated polyamidoamine (PAMAM) dendrimer (G4-SA) was evaluated as a means of preventing adhesion of 3 influenza A subtypes (H1N1, H2N2, and H3N2). In hemagglutination-inhibition assays, G4-SA was found to inhibit all H3N2 and 3 of 5 H1N1 influenza subtype strains at concentrations 32–170 times lower than those of SA monomers. In contrast, G4-SA had no ability to inhibit hemagglutination with H2N2 subtypes or 2 of 5 H1N1 subtype strains. In vivo experiments showed that G4-SA completely prevented infection by a H3N2 subtype in a murine influenza pneumonitis model but was not effective in preventing pneumonitis caused by an H2N2 subtype. Polyvalent binding inhibitors have potential as antiviral therapeutics, but issues related to strain specificity must be resolved</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baker, James R" sort="Baker, James R" uniqKey="Baker J" first="James R." last="Baker">James R. Baker</name><name sortKey="Cao, Zhengyi" sort="Cao, Zhengyi" uniqKey="Cao Z" first="Zhengyi" last="Cao">Zhengyi Cao</name><name sortKey="Galecki, Andrzej T" sort="Galecki, Andrzej T" uniqKey="Galecki A" first="Andrzej T." last="Galecki">Andrzej T. Galecki</name><name sortKey="Hamouda, Tarek" sort="Hamouda, Tarek" uniqKey="Hamouda T" first="Tarek" last="Hamouda">Tarek Hamouda</name><name sortKey="Landers, Jeffrey J" sort="Landers, Jeffrey J" uniqKey="Landers J" first="Jeffrey J." last="Landers">Jeffrey J. Landers</name><name sortKey="Lee, Inhan" sort="Lee, Inhan" uniqKey="Lee I" first="Inhan" last="Lee">Inhan Lee</name><name sortKey="Myc, Andrzej" sort="Myc, Andrzej" uniqKey="Myc A" first="Andrzej" last="Myc">Andrzej Myc</name><name sortKey="Myc, Piotr P" sort="Myc, Piotr P" uniqKey="Myc P" first="Piotr P." last="Myc">Piotr P. Myc</name><name sortKey="Piehler, Lars T" sort="Piehler, Lars T" uniqKey="Piehler L" first="Lars T." last="Piehler">Lars T. Piehler</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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